Opportunity Information: Apply for RFA DE 20 005
The National Dental Practice-Based Research Network (DPBRN) Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement is a National Institutes of Health (NIH), Department of Health and Human Services funding opportunity that supports real-world dental research conducted through the DPBRN infrastructure. It is designed for teams that want to run either a clinical observational study or a clinical trial in everyday dental practice settings, using the Network's established platform for recruiting practices and patients, collecting data, and coordinating multi-site research. The mechanism is milestone-driven, meaning applicants are expected to lay out clear, measurable goals and timelines, and progress against those milestones determines whether the project advances from planning into full implementation.
The award uses a two-phase UG3/UH3 cooperative agreement structure. The UG3 phase functions as a clinical study planning period, where awardees finalize protocols, address regulatory and operational requirements, prepare study materials, and demonstrate readiness to launch. If the UG3 milestones are met, the project can transition to the UH3 phase, which supports the actual implementation of the study, including participant enrollment, data collection, ongoing monitoring, and analysis activities consistent with the approved plan. Across both phases, the combined project period can be as long as six years, giving enough runway for careful preparation followed by full execution in a practice-based environment.
This opportunity is issued as a cooperative agreement rather than a standard grant, which signals substantial NIH involvement during the project. In practice, that usually means the NIH and the DPBRN program leadership may have an active role in coordinating expectations, monitoring milestones, and helping ensure the study aligns with network capabilities, quality standards, and participant protections. The intent is to make the most of the DPBRN's centralized resources and operational experience so that funded projects can move efficiently from planning to implementation while maintaining rigor and consistency across participating dental sites.
Eligibility is broad and includes many types of domestic organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as described in the funding announcement's additional eligibility information. This wide eligibility reflects the applied, practice-based nature of the program and the range of institutions that may be positioned to lead research in dental care settings.
From an administrative standpoint, the opportunity is identified as RFA-DE-20-005 and falls under the Health activity category, with CFDA number 93.121. The announcement was created on October 17, 2019, with an original application closing date of February 10, 2020. The expected number of awards was four. The listed award ceiling is shown as 0, which typically indicates that a specific upper cap was not stated in that field and that applicants need to rely on the FOA text for budget expectations, allowable costs, and any institute-specific funding guidance.
Overall, the program is aimed at supporting high-value dental research that can be carried out efficiently in real clinical settings, emphasizing careful up-front planning, clearly defined milestones, and the ability to scale into full study implementation using DPBRN's existing network resources.Apply for RFA DE 20 005
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "National Dental Practice-Based Research Network Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on Oct 17, 2019.
- Applicants must submit their applications by Feb 10, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: National Dental Practice-Based Research Network (DPBRN) Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement (RFA-DE-20-005)
1) What is this funding opportunity?
This is a National Institutes of Health (NIH), Department of Health and Human Services funding opportunity that supports real-world dental research conducted through the National Dental Practice-Based Research Network (DPBRN) infrastructure. It is intended to help teams plan and then carry out either a clinical observational study or a clinical trial in everyday dental practice settings using the Network's established platform.
2) What kinds of studies does this program support?
The opportunity supports two main types of clinical research conducted in routine dental practice environments:
- Clinical observational studies
- Clinical trials
3) What is the DPBRN and how is it used in this program?
DPBRN is the National Dental Practice-Based Research Network infrastructure used to run practice-based dental research. In this program, teams are expected to leverage the Network's established platform for recruiting practices and patients, collecting data, and coordinating multi-site research across participating dental sites.
4) What does "real-world" or "practice-based" research mean here?
In this context, it means the research is conducted in everyday dental practice settings rather than only in tightly controlled research facilities. The program emphasizes studies that fit into real clinical environments while maintaining research rigor and consistency across sites.
5) What is the funding mechanism for this opportunity?
The award uses a two-phase UG3/UH3 cooperative agreement structure. It is milestone-driven, meaning applicants must propose clear, measurable goals and timelines, and progress against those milestones helps determine whether the project moves from planning into full implementation.
6) What is the UG3 phase?
The UG3 phase is the clinical study planning period. During UG3, awardees finalize study protocols, address regulatory and operational requirements, prepare study materials, and demonstrate readiness to launch the study.
7) What is the UH3 phase?
The UH3 phase supports the actual implementation of the study after UG3 milestones are met. UH3 activities include participant enrollment, data collection, ongoing monitoring, and analysis activities consistent with the approved plan.
8) Does a project automatically move from UG3 to UH3?
No. Transition from UG3 (planning) to UH3 (implementation) is contingent on meeting the UG3 milestones. The program is designed so that progress against defined milestones determines whether the project advances to full implementation.
9) How long can the overall project last?
Across both phases combined, the total project period can be as long as six years. This is intended to provide enough time for careful preparation followed by full execution in a practice-based environment.
10) What does it mean that this is a cooperative agreement rather than a standard grant?
A cooperative agreement signals substantial NIH involvement during the project. In practice, NIH and DPBRN program leadership may take an active role in coordinating expectations, monitoring milestones, and helping ensure the study aligns with network capabilities, quality standards, and participant protections.
11) What is meant by "milestone-driven" in this program?
"Milestone-driven" means applicants are expected to lay out clear, measurable goals and timelines. Progress toward these milestones is used to judge readiness to move from the planning phase (UG3) into the implementation phase (UH3).
12) Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations and government entities. Eligible applicants listed in the opportunity include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofit organizations (501(c)(3) and non-501(c)(3)), excluding higher education institutions in those nonprofit categories
- For-profit organizations other than small businesses
- Small businesses
- Other entities as described in the funding announcement's additional eligibility information
13) Is this opportunity limited to academic institutions?
No. The eligibility list includes academic institutions, but it also includes a wide range of other domestic organizations and government entities, including nonprofits, for-profits, and government bodies. The wide eligibility reflects the applied, practice-based nature of the program.
14) How many awards were expected to be made?
The expected number of awards listed for this opportunity was four.
15) What is the opportunity number and who issues it?
The funding opportunity is identified as RFA-DE-20-005 and is issued under NIH, Department of Health and Human Services.
16) What is the activity category and CFDA number?
The opportunity falls under the Health activity category and lists CFDA number 93.121.
17) When was the announcement created and when was the original application closing date?
The announcement was created on October 17, 2019, and the original application closing date was February 10, 2020.
18) Is there a stated maximum (ceiling) award amount?
The listed award ceiling is shown as 0. This typically indicates that a specific upper cap was not stated in that field, and that applicants should rely on the funding opportunity announcement text for budget expectations, allowable costs, and any institute-specific funding guidance.
19) What kinds of activities are supported during implementation?
During the UH3 implementation phase, supported activities include participant enrollment, data collection, ongoing monitoring, and analysis activities that are consistent with the approved plan and coordinated through the DPBRN infrastructure.
20) What is the overall goal of this program?
The program aims to support high-value dental research that can be carried out efficiently in real clinical settings. It emphasizes careful up-front planning, clearly defined milestones, and the ability to scale into full study implementation using DPBRN's existing network resources.
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