Opportunity Information: Apply for RFA DA 23 052
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), released this funding opportunity to create and support a dedicated Coordinating Center for its HIV/AIDS and Substance Use Cohorts Program. NIDA already funds multiple longitudinal cohort studies that follow participants over time to answer urgent and emerging questions about HIV in the context of injection and non-injection substance use. These cohorts collectively generate valuable clinical and behavioral data, as well as biospecimens, that can be used to study HIV pathogenesis, prevention, treatment outcomes, and the many co-morbidities and co-infections that often intersect with substance use. The central idea behind the grant is that, while each cohort produces important findings on its own, the program becomes far more powerful when data and resources can be harmonized, shared, and accessed efficiently across studies and by outside investigators.
The award mechanism is a U24 cooperative agreement, which means NIH expects substantial involvement from the agency in guiding and partnering on the work rather than simply providing funds and stepping back. The opportunity is explicitly "Clinical Trial Not Allowed," so the Coordinating Center is not meant to run interventional clinical trials. Instead, it is meant to enable, strengthen, and accelerate observational and collaborative research by improving coordination, standardization, and access to program resources. In practice, the Coordinating Center is expected to serve as the operational and scientific hub that helps the various NIDA-funded cohorts work together more seamlessly and that makes it easier for researchers who are not directly funded under the cohort program to collaborate with cohort investigators.
A major expected function is to maximize the value of the cohorts existing data and biospecimens. That includes building systems and processes that make collaboration efficient and scientifically rigorous, such as supporting cross-cohort analyses, encouraging common measures or harmonized data elements where feasible, and reducing friction around data use agreements, metadata documentation, and standardized procedures. The Coordinating Center is also expected to establish a virtual repository. In this context, a virtual repository generally means an organized, searchable, governed platform that points to, catalogs, or provides controlled access to datasets and specimen-related information across cohorts, rather than a single physical biobank. This kind of infrastructure typically focuses on discoverability, consistent documentation, clear governance rules, and streamlined request and review workflows so investigators can identify what exists and how to request it.
The opportunity also emphasizes leadership and facilitation responsibilities. The Coordinating Center is expected to support and help lead the Cohorts Steering Committee, which is made up of representatives from the NIDA-funded cohorts along with NIDA staff. This Steering Committee structure is meant to set priorities, coordinate joint activities, and guide program-wide decisions. The Coordinating Center would typically handle core Steering Committee operations such as meeting planning, agenda development, minutes and follow-up tracking, working group coordination, and communications that keep multiple research teams aligned. By doing this, the center helps ensure that the cohorts do not operate in isolation and that the program can respond quickly when new public health or scientific questions arise.
Eligibility is broad and includes many types of domestic organizations: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized governments; public housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The announcement also calls out several categories of "other eligible applicants," including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Foreign institutions and other non-U.S. entities are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components as defined by the NIH Grants Policy Statement are allowed, which typically means a U.S. applicant can include certain well-justified international collaborations or activities under NIH rules even though a foreign institution cannot serve as the applicant organization.
Administratively, the opportunity is listed as discretionary funding and sits within the education and health activity category, with CFDA number 93.279. The funding opportunity number is RFA-DA-23-052, and the sponsoring agency is NIH (specifically NIDA). The original closing date shown is August 10, 2022, and the mechanism is a cooperative agreement, signaling the expectation of active NIH involvement in shaping and overseeing the Coordinating Center's work. The award ceiling and expected number of awards were not specified in the provided listing, so interested applicants would normally confirm budget expectations and award volume in the full NIH funding opportunity announcement and related notices.
Overall, this grant opportunity is about building the connective tissue for a national research resource: a Coordinating Center that can organize, govern, and amplify the scientific output of NIDA-funded HIV and substance use cohorts. The goal is not to replace the cohorts or redirect their science, but to make the entire program more collaborative, more accessible, and more responsive by improving coordination, creating a robust virtual repository for data and biospecimen-related resources, and providing strong operational leadership for the program's Steering Committee.Apply for RFA DA 23 052
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2022-06-13.
- Applicants must submit their applications by 2022-08-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIDA HIV/AIDS and Substance Use Cohorts Program Coordinating Center (RFA-DA-23-052)
What is this funding opportunity about?
This opportunity from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), supports the creation and operation of a dedicated Coordinating Center for NIDA's HIV/AIDS and Substance Use Cohorts Program. The Center is intended to help multiple NIDA-funded longitudinal cohort studies work together more effectively by improving coordination, standardization, and access to shared resources like data and biospecimens.
Which agency is sponsoring the opportunity?
The sponsoring agency is NIH, specifically NIDA (National Institute on Drug Abuse).
What is the funding opportunity number?
The funding opportunity number is RFA-DA-23-052.
What is the award mechanism?
The mechanism is a U24 cooperative agreement.
What does a U24 cooperative agreement imply for how the project will be run?
A cooperative agreement indicates NIH expects substantial involvement in the project. In practical terms, NIDA staff are expected to actively guide and partner on the Coordinating Center's work rather than only providing funding with minimal ongoing involvement.
Are clinical trials allowed under this opportunity?
No. The opportunity is explicitly listed as "Clinical Trial Not Allowed." The Coordinating Center is not intended to conduct interventional clinical trials.
If clinical trials are not allowed, what kinds of activities is the Coordinating Center meant to support?
The Center is intended to enable and accelerate observational and collaborative research across existing cohorts. Expected activities include improving coordination across studies, supporting cross-cohort analyses, encouraging harmonized measures where feasible, and making it easier for investigators to discover and request access to data and biospecimen-related resources.
What is the overall goal of the Coordinating Center?
The core goal is to maximize the value of the existing cohort program by harmonizing and sharing data and resources more efficiently, strengthening collaboration among cohorts, and improving access for researchers (including investigators who are not directly funded under the cohort program).
What types of studies are involved in the broader cohorts program?
NIDA already funds multiple longitudinal cohort studies that follow participants over time to address urgent and emerging questions about HIV in the context of injection and non-injection substance use.
What types of resources do the cohorts generate that the Coordinating Center will help leverage?
The cohorts collectively generate clinical data, behavioral data, and biospecimens. These resources can support research on HIV pathogenesis, prevention, treatment outcomes, and co-morbidities and co-infections that intersect with substance use.
How is the Coordinating Center expected to make cross-cohort work easier?
The Center is expected to build systems and processes that reduce barriers to collaboration, such as supporting cross-cohort analyses, encouraging common measures or harmonized data elements where feasible, improving metadata documentation, and reducing friction around data use agreements and standardized procedures.
What is meant by a "virtual repository" in this opportunity?
In this context, a virtual repository generally refers to an organized, searchable, governed platform that catalogs, points to, or provides controlled access to datasets and specimen-related information across multiple cohorts. It is not described as a single physical biobank; it emphasizes discoverability, consistent documentation, governance rules, and streamlined request/review workflows.
Does the opportunity require building a physical biobank?
Based on the information provided, the emphasis is on a virtual repository (a platform for discovery and controlled access) rather than creating a single centralized physical biobank.
Who will use the Coordinating Center's systems and resources?
The Coordinating Center is intended to support both: (1) the investigators and teams running the NIDA-funded cohorts, and (2) outside investigators who are not directly funded under the cohort program but wish to collaborate with cohort investigators and access program resources through appropriate governance and request processes.
What governance or leadership role is the Coordinating Center expected to play?
The Center is expected to support and help lead the Cohorts Steering Committee, which includes representatives from the NIDA-funded cohorts and NIDA staff. This structure is intended to set priorities, coordinate joint activities, and guide program-wide decisions.
What operational tasks might the Coordinating Center handle for the Steering Committee?
The Coordinating Center would typically manage core operations such as meeting planning, agenda development, minutes, follow-up tracking, working group coordination, and communications that keep multiple research teams aligned.
Why is the Steering Committee important to this program?
The Steering Committee is described as a way to ensure the cohorts do not operate in isolation and that the program can respond quickly to new public health or scientific questions by coordinating priorities and joint activities across cohorts.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.279.
How is the opportunity categorized administratively?
It is listed as discretionary funding and is placed within the education and health activity category.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. (domestic) organizations, including state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized governments; public housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses.
Are there specific categories of "other eligible applicants" called out?
Yes. The announcement calls out Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are foreign institutions eligible to apply as the applicant organization?
No. Foreign institutions and other non-U.S. entities are not eligible to apply as the applicant organization.
Are non-domestic components of U.S. organizations eligible?
No. Non-domestic components of U.S. organizations are also not eligible to apply.
Are any international activities allowed at all?
Yes, foreign components (as defined by the NIH Grants Policy Statement) are allowed. This typically means a U.S. applicant may include certain justified international collaborations or activities under NIH rules, even though a foreign institution cannot be the applicant.
What was the original closing date shown in the listing?
The original closing date shown is August 10, 2022.
Is the award ceiling listed?
No. The award ceiling was not specified in the provided listing.
Is the expected number of awards listed?
No. The expected number of awards was not specified in the provided listing.
What should applicants do if they need budget expectations or award volume?
Because the award ceiling and expected number of awards were not provided here, applicants would typically confirm budget expectations and award volume in the full NIH funding opportunity announcement and any related notices.
Does the Coordinating Center replace the individual cohorts or redirect their science?
No. The goal is described as building "connective tissue" for the program. The Coordinating Center is intended to organize, govern, and amplify the scientific output of the existing cohorts, not replace them or redirect their individual research aims.
What is the main value-add of the Coordinating Center compared to cohorts working independently?
While each cohort can produce important findings independently, the program becomes more powerful when data and resources can be harmonized, shared, and accessed efficiently across studies and by outside investigators. The Coordinating Center is meant to enable that program-wide efficiency and collaboration.
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