Opportunity Information: Apply for RFA CA 20 013
Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional), RFA-CA-20-013, is a National Cancer Institute (NCI) funding opportunity designed specifically for projects that already hold an active NCI U24 cooperative agreement for resource-related research. The goal is not to start a brand-new standalone effort, but to fund a revision (formerly called a competing revision) that meaningfully extends or accelerates the parent U24 project by incorporating cancer informatics technologies created through the NCI Informatics Technology for Cancer Research (ITCR) Program. In practical terms, the FOA is trying to speed the path from informatics tool development to real-world use in cancer research communities by encouraging teams who run established U24 resources to adopt, adapt, and integrate proven ITCR-supported methods, tools, or platforms into their ongoing work.
The core purpose is to stimulate novel collaborations and interdisciplinary integration. Many ITCR outputs are advanced software tools, data standards, analytic methods, and infrastructure components that can be highly impactful but require real deployment contexts, domain-specific tailoring, user support, and integration with existing research workflows to achieve broad uptake. This FOA is meant to incentivize exactly that step: taking informatics technology that has already been developed with ITCR support (current or prior) and embedding it into an active U24 resource project in a way that expands the original scientific questions, enables additional capabilities, or accelerates progress for the parent study. The larger programmatic intent is to enhance cancer research productivity and speed discovery by improving how researchers collect, manage, harmonize, analyze, and share data.
The mechanism is a cooperative agreement (U24), which generally means NCI expects substantial scientific and/or programmatic involvement during the project period, beyond what is typical for a standard grant. The FOA is labeled “Clinical Trial Optional,” indicating that proposed activities may include a clinical trial if appropriate, but a clinical trial is not required. The funding instrument falls under the broad activity category of education and health, and it is associated with CFDA number 93.396. The sponsoring agency is the U.S. Department of Health and Human Services, National Institutes of Health (NIH), specifically NCI.
Funding is relatively modest and targeted to the revision scope: the listed award ceiling is $100,000, and NCI anticipated making about four awards under this announcement. This structure signals that the revisions are expected to be focused, high-leverage add-ons that enable integration or deployment of ITCR technologies rather than large expansions of the parent program. The FOA was created on January 23, 2020, and the original closing date was November 18, 2020.
Eligibility is broad in a general sense (including various government entities, higher education institutions, nonprofits, for-profits, and small businesses), but the key practical constraint is embedded in the purpose statement: applications are meant to be revision requests from “currently funded NCI U24 resource-related research projects.” In other words, the applicant organization must already be the recipient of a qualifying NCI U24 award and must be proposing a revision to that active parent award. The revision must clearly build on the existing aims or accelerate the parent project by bringing in informatics methods, tools, or resources that were developed with ITCR program support, and it should be framed in terms of adoption, adaptation, integration, and community benefit rather than purely exploratory development.
Overall, this FOA is best understood as a bridge between informatics innovation and operational cancer research infrastructure. It aims to move ITCR-funded technologies into the hands of researchers and resource programs that can validate them at scale, improve them through real-world use, and embed them into widely used platforms or services, thereby expanding the reach and impact of NCI’s informatics investments.Apply for RFA CA 20 013
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on Jan 23, 2020.
- Applicants must submit their applications by Nov 18, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: RFA-CA-20-013 (U24 Clinical Trial Optional)
What is the full title of this funding opportunity?
The opportunity is titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trial Optional)" and is identified as RFA-CA-20-013.
Which agency is offering this opportunity?
The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), specifically the National Cancer Institute (NCI).
What is the main purpose of this FOA?
The purpose is to fund a revision (formerly called a competing revision) to an already-active NCI U24 cooperative agreement for resource-related research, so that the parent U24 project can meaningfully extend or accelerate its work by incorporating cancer informatics technologies created through the NCI Informatics Technology for Cancer Research (ITCR) Program.
Is this intended to fund a brand-new standalone project?
No. This FOA is designed for revisions to existing, currently funded NCI U24 resource-related research projects. It is not intended to start a brand-new standalone effort.
What does "revision" mean in this context?
In this context, a revision is a request to modify and expand the scope of an active parent award. The FOA describes it as a "revision (formerly called a competing revision)" that should extend or accelerate the parent U24 by integrating ITCR-supported informatics technologies.
What types of technologies or outputs are meant to be incorporated?
The FOA emphasizes cancer informatics technologies created through the NCI ITCR Program, including advanced software tools, data standards, analytic methods, and infrastructure components that have already been developed with ITCR support (current or prior).
What kinds of activities is the FOA trying to encourage?
The FOA is aimed at adoption, adaptation, and integration of ITCR-supported methods, tools, or platforms into an active U24 resource project. It is designed to support real deployment contexts, domain-specific tailoring, user support, and integration with existing research workflows to increase uptake in cancer research communities.
What is the broader programmatic goal behind this FOA?
The broader intent is to speed the path from informatics tool development to real-world use in cancer research by embedding proven ITCR-supported technologies into established U24 resources. The FOA frames this as improving cancer research productivity and speeding discovery by strengthening how researchers collect, manage, harmonize, analyze, and share data.
What does the funding mechanism "U24 cooperative agreement" imply?
A U24 cooperative agreement indicates that NCI expects substantial scientific and/or programmatic involvement during the project period, beyond what is typical for a standard grant.
Are clinical trials required under this FOA?
No. The FOA is labeled "Clinical Trial Optional," meaning a clinical trial may be included if appropriate, but a clinical trial is not required.
What is the award ceiling (maximum funding amount) for this opportunity?
The listed award ceiling is $100,000, indicating the revisions are expected to be focused, high-leverage additions rather than large expansions of the parent program.
How many awards did NCI anticipate making?
NCI anticipated making about four awards under this announcement.
When was this FOA created and when did it close?
The FOA was created on January 23, 2020, and the original closing date was November 18, 2020.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.396.
Who is eligible to apply?
The FOA lists broad categories of eligible applicants (including various government entities, higher education institutions, nonprofits, for-profits, and small businesses). However, the key practical eligibility requirement is that applications are intended as revision requests from currently funded NCI U24 resource-related research projects. In practice, the applicant organization must already be the recipient of a qualifying active NCI U24 award and must be proposing a revision to that parent award.
What is the most important eligibility constraint to keep in mind?
The most important constraint is that the application must be a revision to a currently active NCI U24 cooperative agreement for resource-related research. The FOA is specifically designed for teams with an existing NCI U24 resource project seeking to incorporate ITCR-developed technologies into that ongoing effort.
How should a proposed revision be positioned to fit the FOA?
Based on the FOA description, the revision should clearly build on the existing aims or accelerate progress on the parent U24 by bringing in informatics methods, tools, or resources developed with ITCR support. The emphasis should be on adoption, adaptation, integration, and community benefit, rather than purely exploratory tool development.
What does the FOA mean by stimulating collaborations and interdisciplinary integration?
The FOA aims to stimulate novel collaborations by connecting established U24 resource teams with proven ITCR-supported technologies. The goal is interdisciplinary integration where informatics methods and platforms are embedded into real cancer research infrastructure and workflows to achieve broader use and impact.
Why is this FOA described as a bridge between innovation and operational infrastructure?
Because it is designed to move ITCR-funded technologies from development into real-world use by established U24 resources that can deploy them at scale, improve them through real-world feedback, and embed them into widely used platforms or services.
What kind of scope does the funding level suggest?
With a $100,000 award ceiling and an emphasis on revisions, the FOA suggests a targeted scope: focused, high-leverage integration or deployment work that extends or accelerates the parent U24 resource project, rather than a major expansion or a separate new program.
What outcomes is NCI trying to achieve through these revisions?
The FOA is trying to increase real-world uptake of ITCR-supported informatics tools and methods, expand capabilities within existing U24 resources, and enhance community benefit by improving data-related processes in cancer research, including data collection, management, harmonization, analysis, and sharing.
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