Pancreatic Ductal Adenocarcinoma Stromal Reprogramming Consortium Coordinating and Data Management Center (PSRC CDMC) (U24 Clinical Trial Not Allowed) | RFA CA 21 042

Opportunity Information: Apply for RFA CA 21 042

The Pancreatic Ductal Adenocarcinoma Stromal Reprogramming Consortium Coordinating and Data Management Center (PSRC CDMC) funding opportunity (RFA-CA-21-042) is an NIH cooperative agreement (U24) designed to stand up a central hub that supports the broader PDAC Stromal Reprogramming Consortium (PSRC), which is funded through companion U01 research project awards under RFA-CA-21-041. The main point of this FOA is not to fund another standalone laboratory research project, but to fund the coordinating backbone that keeps a multi-site consortium functioning smoothly and producing integrated, comparable, high-quality outputs. The FOA is explicitly marked "Clinical Trial Not Allowed," meaning applicants should not propose a clinical trial as part of this U24 scope.

At a high level, NIH is looking for a multidisciplinary team that can build and operate the infrastructure needed to coordinate consortium-wide administrative operations, collaboration, outreach, and especially data management activities that serve all participating PSRC research projects. In practical terms, the CDMC would typically be responsible for organizing consortium communications and meetings, setting up consistent operating procedures across sites, tracking milestones and progress, supporting governance and decision-making processes, and creating the systems that allow data and related resources to be collected, curated, harmonized, shared, and analyzed across the consortium. Because this is a cooperative agreement, the award mechanism also signals that NIH program staff are expected to have substantial involvement in steering and monitoring activities compared with a standard grant.

The scope emphasizes consortium enablement: the CDMC should facilitate collaboration among the U01 project teams, reduce friction in multi-institution work, and make sure data management is handled in a way that supports cross-project integration. That generally implies building or leveraging secure platforms for data submission and access, establishing data standards and common data elements when relevant, implementing quality control checks, maintaining documentation and metadata, and supporting timely sharing consistent with NIH expectations. The outreach component suggests the center may also help coordinate external-facing communications and engagement activities that broaden the impact of the consortium's work, such as disseminating resources, guidelines, datasets, or other products to the wider research community, while staying aligned with NIH policies.

Eligibility is broad and includes many common U.S. applicant types: state, county, city, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); small businesses; and other entities that meet NIH eligibility rules. The FOA also calls out additional eligible categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, tribally controlled colleges and universities, faith-based or community-based organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, there are clear restrictions on foreign participation: non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" as defined by the NIH Grants Policy Statement are allowed, which typically means a U.S.-based applicant organization can include certain international elements in the project when scientifically justified and compliant with NIH policy, even though a foreign institution cannot be the applicant organization.

The opportunity falls under NIH program areas associated with CFDA numbers 93.394 and 93.395, and it is categorized under education and health. The FOA was created on July 26, 2021, with an original closing date of November 1, 2021. The listed award ceiling is $600,000, and the expected number of awards is not specified in the provided listing. Overall, the solicitation is aimed at applicants that can credibly demonstrate they have (or can rapidly assemble) the operational capacity, project management expertise, informatics and data governance capabilities, and collaborative infrastructure to function as the central coordinating and data management engine for a complex pancreatic cancer stromal reprogramming research consortium.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Pancreatic Ductal Adenocarcinoma Stromal Reprogramming Consortium Coordinating and Data Management Center (PSRC CDMC) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
• This funding opportunity was created on 2021-07-26.
• Applicants must submit their applications by 2021-11-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $600,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 21 042

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: