Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required) | PAR 25 098

Opportunity Information: Apply for PAR 25 098

PAR-25-098 is an NIH R01 funding opportunity led by the Office of Disease Prevention (ODP) and multiple participating NIH Institutes, Centers, and Offices to support research that directly tests interventions aimed at increasing the use, uptake, and successful completion of cancer screening and related preventive services in populations that experience health disparities. The core purpose is practical and implementation-focused: identify and address the real-world barriers (and leverage facilitators) that keep people from getting screened, receiving preventive services, completing the care process after an abnormal finding, and ultimately getting connected to accessible, appropriate follow-up care. Because it is labeled "Clinical Trial Required," applicants are expected to conduct a trial that evaluates the intervention(s) in a rigorous way, rather than only planning, observational work, or descriptive studies.

The opportunity emphasizes interventions that go beyond simply offering screening and instead improve the full pathway of prevention and early detection. NIH is interested in projects that can move the needle on processes such as getting eligible patients into screening, ensuring timely follow-up of abnormal or positive results, reducing delays and drop-off between steps, and improving referral and linkage to accessible care when additional diagnostic work or treatment is needed. In other words, the intervention can be targeted to screening itself, to preventive services, or to surrounding healthcare processes that determine whether screening actually leads to better outcomes (for example, navigation, reminder systems, care coordination, referral management, or systems that reduce missed follow-up).

A central design expectation is that interventions address barriers and facilitators at two or more levels of influence. NIH specifically names the patient level, clinician level, healthcare setting level, and neighborhood or community level. This means competitive projects will typically be multi-level, such as pairing patient navigation with clinician decision support, or combining community outreach with clinic workflow changes, or integrating culturally tailored education with health system tracking and follow-up systems. The multi-level requirement is meant to reflect how disparities in screening and prevention are produced by overlapping factors, including individual constraints, provider practices, institutional capacity and workflow, and community conditions like transportation, trust, access, and local resources.

Collaboration is strongly encouraged, particularly with community partners and service providers. The notice signals that NIH is looking for projects designed with the settings and populations in mind, not imposed from the outside. Applicants are encouraged to build meaningful partnerships with organizations that can help with recruitment, intervention delivery, sustainability, and real-world feasibility, such as community-based groups, faith-based organizations, clinics, health systems, public health agencies, and other local service providers. Participating NIH components also list specific research interests within the full announcement, so applicants are expected to align their proposed cancer focus, population, setting, and intervention approach with those stated priorities.

Eligibility is broad and includes many types of U.S.-based entities: state, county, city/township, and special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; tribal organizations that are not federally recognized; nonprofits with or without 501(c)(3) status (other than IHEs); for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible applicant categories that are often central to disparity-focused work, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

At the same time, there are clear restrictions around foreign involvement. Non-domestic (non-U.S.) entities are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, meaning a U.S. applicant may include certain foreign elements in the project when justified and compliant with NIH policy, but the applying institution itself must be domestic.

Administrative details provided in the source information include the funding opportunity number (PAR-25-098), the activity mechanism (R01), the agency (NIH), and the broad activity category of education and health. The CFDA/assistance listing numbers associated with the opportunity include 93.121, 93.307, 93.313, and 93.399. The posting indicates an original closing date of January 7, 2027. The award ceiling and expected number of awards are not specified in the provided extract, which typically means applicants should refer to the full funding opportunity announcement for budget expectations, project period norms, and any institute-specific guidance.

Overall, this R01 is aimed at producing actionable evidence on multi-level interventions that can measurably improve cancer screening and prevention-related care processes for populations experiencing disparities, with an explicit expectation of partnership, real-world implementation relevance, and rigorous trial-based evaluation that includes the steps after screening, such as timely follow-up and effective referral to accessible care.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.307, 93.313, 93.399.
• This funding opportunity was created on 2024-10-10.
• Applicants must submit their applications by 2027-01-07.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 25 098

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