Opportunity Information: Apply for RFA DK 26 310
The Diabetes Research Centers (P30 Clinical Trial Optional) funding opportunity (RFA-DK-26-310) is a National Institutes of Health (NIH) center grant designed to strengthen and coordinate the national research effort focused on diabetes, its complications, and closely related endocrine and metabolic diseases. The core idea is to fund an institutional "center" structure that makes many investigators more effective together than they would be working separately on individual project grants. These Diabetes Research Centers (DRCs) are expected to connect basic science and clinical research communities, improve day-to-day communication across disciplines, and create a setting where collaborative, multidisciplinary work becomes easier to start and sustain.
A central requirement of a DRC is the provision of shared, specialized research resources through "cores." These cores are meant to function as high-value, centralized capabilities (for example, specialized assays, biostatistics support, data management, clinical research support resources, or other advanced technical services) that multiple research teams can access. The intent is to reduce duplication across labs, raise technical quality through dedicated expertise, and speed up progress by making key tools and services readily available to the broader diabetes research community at the applicant institution. Alongside the cores, each DRC must support a Pilot and Feasibility (P&F) Program, which typically provides smaller, targeted awards to help investigators launch new lines of investigation, generate preliminary data, test novel ideas, or bring new researchers into diabetes-related work. In practical terms, the P&F program is one of the main ways a center can stimulate innovation, seed high-risk/high-reward projects, and help investigators become competitive for larger independent grants later.
The NOFO encourages new or refreshed center programs that add real value rather than simply rebadging existing activities. Applications that introduce diverse perspectives, build around distinctive scientific themes, or offer innovative resources are specifically welcomed. Review emphasis is also expected to favor centers that can demonstrate meaningful synergy with other National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded efforts, suggesting that alignment and coordination with existing NIDDK programs, networks, or institutional strengths will matter. Another highlighted expectation is a strong mentoring and training environment, with the center positioned as a hub that supports the development of future diabetes researchers through structured opportunities, access to expertise, and an ecosystem that helps early-stage investigators grow.
This is a discretionary grant program in the health category, administered by NIH under CFDA 93.847. The funding instrument is a P30 center grant, and the "Clinical Trial Optional" designation indicates that clinical trials may be included when appropriate, but they are not mandatory for the application. The opportunity lists an expected number of awards of 7, with an award ceiling of $1,000,000 (as stated in the source data). The original application closing date is January 27, 2027.
Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, state and local governments, certain tribal governments and tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses, among others as listed in the opportunity. At the same time, there are strict limitations on foreign involvement: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. A key administrative constraint is that only one application is permitted per institution, which means institutions must coordinate internally to submit a single, consolidated proposal representing their strongest plan for a Diabetes Research Center.
Overall, the opportunity is aimed at building or strengthening institutional center infrastructure that can serve a broad diabetes research community, expand collaborative capacity through shared cores, accelerate new ideas through pilot funding, and create a productive pipeline of well-mentored investigators. The most competitive proposals are likely to be those that clearly show how the center structure will measurably improve research productivity and quality beyond what individual grants can accomplish, while also demonstrating innovative resources, strong interdisciplinary integration, and clear connections to the larger NIDDK-supported research ecosystem.Apply for RFA DK 26 310
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Diabetes Research Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2025-12-05.
- Applicants must submit their applications by 2027-01-27.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Diabetes Research Centers (P30 Clinical Trial Optional) - RFA-DK-26-310
What is this funding opportunity?
This opportunity is the Diabetes Research Centers (P30 Clinical Trial Optional) funding opportunity (RFA-DK-26-310), a National Institutes of Health (NIH) center grant intended to strengthen and coordinate research focused on diabetes, its complications, and closely related endocrine and metabolic diseases.
What is the purpose of a Diabetes Research Center (DRC)?
The purpose of a DRC is to create an institutional "center" structure that makes investigators more effective together than they would be through separate individual project grants. The DRC model is intended to improve coordination, communication, and collaboration across disciplines, especially between basic science and clinical research communities.
What does "P30" mean in this announcement?
P30 is the NIH funding mechanism for a center grant. In this context, the P30 supports shared infrastructure and resources (such as cores and a Pilot and Feasibility program) that enable and accelerate research across multiple investigators at an institution.
Is a clinical trial required to apply?
No. The opportunity is labeled "Clinical Trial Optional," meaning clinical trials may be included when appropriate, but they are not required for the application.
What are "cores" and why are they required?
Cores are shared, specialized research resources that multiple research teams can access. They are required because the DRC model is built around centralized, high-value capabilities that reduce duplication across labs, improve technical quality through dedicated expertise, and speed research progress by making key tools and services broadly available.
What kinds of services can cores provide?
The announcement describes cores as centralized capabilities such as specialized assays, biostatistics support, data management, clinical research support resources, or other advanced technical services that can be shared by multiple investigators.
What is the Pilot and Feasibility (P&F) Program?
The P&F Program is a required component of each DRC and typically provides smaller, targeted awards to help investigators launch new research directions, generate preliminary data, test novel ideas, or bring new researchers into diabetes-related work.
Why is the Pilot and Feasibility (P&F) Program important in this center model?
The P&F Program is described as one of the main ways the center stimulates innovation. It can seed high-risk/high-reward projects and help investigators develop the early evidence needed to become competitive for larger independent grants later.
What kinds of research areas does this program focus on?
The opportunity focuses on diabetes, its complications, and closely related endocrine and metabolic diseases, with an emphasis on building a center environment that connects basic and clinical research.
How does this program expect a center to improve research outcomes?
The DRC is expected to measurably improve research productivity and quality beyond what individual grants can accomplish by strengthening day-to-day communication across disciplines, making collaboration easier to initiate and sustain, and providing shared resources through cores and pilot funding.
Does NIH encourage brand-new centers or can existing programs apply?
The announcement encourages new or refreshed center programs that add real value rather than simply rebadging existing activities. Applications that bring distinctive scientific themes, diverse perspectives, or innovative resources are specifically welcomed.
What is meant by "synergy" with other NIDDK-funded efforts?
The opportunity indicates that review emphasis is expected to favor centers that can demonstrate meaningful synergy with other National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-funded efforts. In practice, this suggests alignment and coordination with existing NIDDK programs, networks, or the institution's NIDDK-related strengths will matter.
Is mentoring and training part of what reviewers will look for?
Yes. The opportunity highlights an expectation for a strong mentoring and training environment, with the center acting as a hub that supports development of future diabetes researchers through structured opportunities, access to expertise, and an ecosystem that helps early-stage investigators grow.
Who administers this grant and what is the program category?
This is a discretionary grant program in the health category administered by NIH. The announcement references CFDA 93.847.
How many awards does NIH expect to make?
The opportunity lists an expected number of awards of 7.
What is the maximum award amount listed for this opportunity?
The opportunity lists an award ceiling of $1,000,000 (as stated in the source data provided).
What is the application deadline?
The original application closing date is January 27, 2027.
What types of organizations are eligible to apply?
Eligibility is broad across many U.S.-based organization types. The opportunity lists eligible applicants including (among others) public and private institutions of higher education, state and local governments, certain tribal governments and tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses.
Are foreign organizations eligible to apply?
No. Non-U.S. entities are not eligible to apply.
Can a U.S. organization include a non-U.S. component?
No. The opportunity states that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed in any form?
No. The opportunity states that foreign components (as defined by NIH policy) are not allowed.
How many applications may an institution submit?
Only one application is permitted per institution. This means institutions must coordinate internally to submit a single consolidated proposal representing their strongest plan for a Diabetes Research Center.
What is the main structural idea behind this center grant?
The main structural idea is to fund a coordinated institutional center that provides shared cores and pilot funding to support a broad diabetes research community at the applicant institution, making collaborative, multidisciplinary work easier and more productive.
What kinds of proposals are likely to be most competitive based on the description provided?
Based on the description, the most competitive proposals are likely to be those that clearly demonstrate how the center structure will improve research productivity and quality beyond individual grants, offer innovative shared resources, integrate disciplines (including basic and clinical research), show strong mentoring and training, and demonstrate clear connections to the broader NIDDK-supported research ecosystem.
What is the overarching goal of funding Diabetes Research Centers through this opportunity?
The overarching goal is to build or strengthen institutional center infrastructure that serves a broad diabetes research community, expands collaborative capacity through shared cores, accelerates new ideas through pilot funding, and supports a productive pipeline of well-mentored investigators.
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